Yongzhi Cao

Synergistic Attention-Guided Cascaded Graph Diffusion Model for Complementarity Determining Region Synthesis

2024 · IEEE Transactions on Neural Networks and Learning Systems

Complementarity determining region (CDR) is a specific region in antibody molecules that binds to antigens, where a small portion of residues undergoes particularly pronounced variations. Generating CDRs with high affinity and specificity is a pivotal …