Gordon D. Rubenfeld

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

2016 · JAMA

IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology …

Assessment of Clinical Criteria for Sepsis

2016 · JAMA

IMPORTANCE: The Third International Consensus Definitions Task Force defined sepsis as "life-threatening organ dysfunction due to a dysregulated host response to infection." The performance of clinical criteria for this sepsis definition is unknown. OBJECTIVE: To …