Ben Langmead

Prefix-free parsing for building big BWTs

2019 · Algorithms for Molecular Biology

Abstract High-throughput sequencing technologies have led to explosive growth of genomic databases; one of which will soon reach hundreds of terabytes. For many applications we want to build and store indexes of these databases but …

Accurate short-read alignment through<i>r</i>-index-based pangenome indexing

2025 · Genome Research

Aligning to a linear reference genome can result in a higher percentage of reads going unmapped or being incorrectly mapped owing to variations not captured by the reference, otherwise known as reference bias. Recently, in …