TransReg: Cross-transformer as auto-registration module for multi-view mammogram mass detection

Screening mammography is the most widely used method for early breast cancer detection, significantly reducing mortality rates. The integration of information from multi-view mammograms enhances radiologists' confidence and diminishes false-positive rates since they can examine on dual-view of the same breast to cross-reference the existence and location of the lesion. Inspired by this, we present TransReg, a Computer-Aided Detection (CAD) system designed to exploit the relationship between craniocaudal (CC), and mediolateral oblique (MLO) views. The system includes cross-transformer to model the relationship between the region of interest (RoIs) extracted by siamese Faster RCNN network for mass detection problems. Our work is the first time cross-transformer has been integrated into an object detection framework to model the relation between ipsilateral views. Our experimental evaluation on DDSM and VinDr-Mammo datasets shows that our TransReg, equipped with SwinT as a feature extractor achieves state-of-the-art performance. Specifically, at the false positive rate per image at 0.5, TransReg using SwinT gets a recall at 83.3% for DDSM dataset and 79.7% for VinDr-Mammo dataset. Furthermore, we conduct a comprehensive analysis to demonstrate that cross-transformer can function as an auto-registration module, aligning the masses in dual-view and utilizing this information to inform final predictions. It is a replication diagnostic workflow of expert radiologists