Guoqiang Chen

Accelerating Virtual Directed Evolution of Proteins via Reinforcement Learning

2025 · bioRxiv (Cold Spring Harbor Laboratory)

Abstract With the advancement of machine learning methods, the protein fitness landscape can be predicted, providing reliable guidance in the selection of advantageous mutations for the directed evolution of proteins. However, the potential multiple mutational …

BinMetric: A Comprehensive Binary Code Analysis Benchmark for Large Language Models

2025

Binary analysis is crucial for software security, offering insights into compiled programs without source code. As large language models (LLMs) excel in language tasks, their potential for complex decoding binary data structures is growing. However, …