David A. Relman

Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

2018 · Microbiome

BACKGROUND: The accuracy of microbial community surveys based on marker-gene and metagenomic sequencing (MGS) suffers from the presence of contaminants-DNA sequences not truly present in the sample. Contaminants come from various sources, including reagents. Appropriate …