Charles DeCarli

Regional beta‐amyloid and tau deposition: Results from the Framingham Heart Study

2021 · Alzheimer s & Dementia

Abstract Background The Framingham Heart Study (FHS), a three‐generation community‐based cohort studying cardiovascular disease across the adult lifespan, has expanded to include positron emission tomography (PET) of beta‐amyloid (Aβ) and tau. Our aim is to …

Preanalytic variable effects on segmentation and quantification machine learning algorithms for amyloid-β analyses on digitized human brain slides

2023 · Journal of Neuropathology & Experimental Neurology

Computational machine learning (ML)-based frameworks could be advantageous for scalable analyses in neuropathology. A recent deep learning (DL) framework has shown promise in automating the processes of visualizing and quantifying different types of amyloid-β deposits …